Endocrine Abstracts

Graves’ disease is characterized by the occurrence of antibodies against thyroid-stimulating hormone (TSH) receptor that stimulate the gland to produce T4 and T3. It can be accompanied by an infiltrative orbitopathy and oftalmopathy. Another seldom- regognized feature of this disease is thymic hyperplasia.The authors report the case of a 22-year-old woman with Graves’ disease (TSH receptor antibodies 178 U/l) with exuberant oftalmopathy and an ...

Introduction: Tyrosine Kinase Inhibitors (TKIs) are approved for the treatment of several cancers and can induce hypothyroidism by unclarified mechanisms.Objectives: To assess the prevalence of hypothyroidism in patients treated with TKIs.Methods: Retrospective review of clinical records of patients treated with TKIs in our institution between 2003 and 2009. We evaluated parameters such as sex, oncologic pathology, TKI used, TSH an...

Pheocromocytoma is a catecholamine-secreting tumor that arises from chromaffin cells of the adrenal medulla. In general, they are unilateral and the treatment of choise is complete surgical resection. Surgery and other medical procedures such as chemotherapy or radiotherapy may result in massive catecholamine release that can be fatal. Some form of preoperative pharmacologic preparation is indicated for all patients to control blood pressure, arrhytmia and promote intravascula...